Reconstruction of the cell entry pathway of an extinct virus.
Endogenous retroviruses (ERVs), remnants of ancient germline infections, comprise 8% of the human genome.The most recently integrated includes human ERV-K (HERV-K) where several envelope (env) sequences remain intact.Viral pseudotypes decorated with one of those Envs moen rothbury faucet are infectious.Using a recombinant vesicular stomatitis virus